Aim: To find out the organisms causing 
                              endometritis in cattle and to determine their in 
                              vitro sensitivity to various antibiotics. 
              
              
                              
              
                              Materials and Methods: Thirty uterine 
                              secretion samples, 9 from Holstein Friesian and 21 
                              from Jersey cows were collected in and around 
                              Namakkal district of Tamil Nadu from clinical 
                              cases of endometritis. The bacteria isolated both 
                              aerobically and anaerobically from endometritis 
                              showed the characteristic colony, were gram 
                              stained and confirmed by standard biochemical 
                              tests. The in vitro antibiotic sensitivity 
                              test with different antibiotic discs were carried 
                              out. 
              
                              
              Results: Out of 30 samples, 25 
                              contained different strains of bacteria and 5 were 
                              found bacteriologically sterile. Different species 
                              of bacteria isolated from these samples were, 
                              Escherichia coli (36.66%), Klebsiella spp 
                              (30%), Proteus spp (13.33%), Pseudomonas 
                              aeruginosa (6.66%), Clostridium spp 
                              (3.33%). The in vitro antibiotic 
                              sensitivity test indicated that the highest number 
                              of isolates (64%) were sensitive to Ceftriaxone, 
                              followed by Gentamicin, Enrofloxacin and 
                              Chlortetracycline (32%). Chloramphenicol showed 
                              sensitivity in minimum number (8%) of isolates. 
              
              
                              
              
                              Conclusion: This study revealed that the 
                              bacteria E. coli and Klebisella spp 
                              are more commonly isolated in endometritis in cows 
                              and the drug Ceftriaxone is highly effective. 
              
              
                              
              
                              Keywords: antibiotic sensitivity, 
                              bacteriology, cows, endometritis